I started using TweetDeck more than a year ago and established a HootSuite account last month. Personally, I like HootSuite better. The primary reason is HootSuite is web-based, allowing me access from any Internet-accessible device. I found the setup to be incredible easy, especially since I had experience with the features of TweetDeck.
This tutorial shows you how to establish a HootSuite account and set up you site.
Anyone want to share their experiences with either TweetDeck or HootSuite?